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To promote participant retention, the SCALE Insulin phase 3b trial permitted individuals to stop and restart liraglutide 3.0 mg without re-escalating the dose, or with re-escalation if three consecutive doses had been missed [7]

This aching sensation typically signals chronic inflammation, muscle tension, or organ dysfunction rather than acute tissue damage, making it distinct from sharp pain that indicates immediate injury

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Lee et al., 2017), schizophrenia (Garey, 2010